Time-Fractal Modulation—Possible Modulation Effects in Human Therapy

Andras Szasz

doi:10.4236/ojbiphy.2022.121003

Abstract

The malignant processes deviate from the healthy homeostatic control, and various “tricks” enable malignant cells to avoid the healthy regulation. Consequently, the malignant structures miss the apoptosis and proliferate without restriction, and without the formation of communication networks in the newly formed cells. The modulation supports the homeostatic control to rearrange the health regulation processes in various ways. The modulation acts with stochastic processes, using stochastic resonances for molecular excitations, supporting the regulative enzymatic processes. The number of stochastic resonant frequencies is as many as the number of enzymatic reactions. The malignant cells differ structurally and dynamically in their connections and interactions from their healthy host tissues. The radiofrequency carrier is modulated with an appropriate time-fractal (1/f) noise to select the autonomic cancer-cells, destroy them, or force the precancerous, semi-individual cells to participate in the networking connections. The modulation in this way limits the cellular autonomy of malignant cells and boosts the healthy control. The resonant energy triggers apoptotic processes and helps immunogenic actions deliver extracellular genetic information for antigen-presentation. The modulation is applied in clinical practice. The therapy (modulated electro-hyperthermia, mEHT) is intensively used in oncology in complementary applications and for palliative stages, and occasionally even as a monotherapy.

Highlights

IntroductionThe transformation from the organized multicellular structure seen in healthy tissues to the structure seen in tumors is driven by the primitive transcriptional programs active in malignant cells [1]
The malignant processes deviate from the healthy homeostatic control, and various “tricks” enable malignant cells to avoid the healthy regulation
The modulation acts with stochastic processes, using stochastic resonances for molecular excitations, supporting the regulative enzymatic processes

Summary

Introduction

The transformation from the organized multicellular structure seen in healthy tissues to the structure seen in tumors is driven by the primitive transcriptional programs active in malignant cells [1]. The reorganization of the tumors structure supports the unicellular behavior and autonomy of the malignant cells, promoting the survival of the “colony” of malignant cells [2]. In an attempt to correct the abnormality, the healthy host initiates processes, such as angiogenesis, nerve healing, and numerous other supports, which instead provide essential conditions for the development of the malignancy. This regulation follows the general homeostatic control of the body. Additional challenges which the host must face are the permanent uncontrolled stress on the system exerted by the malignancy [7], the recognition of the lesion as an unhealed wound [8], inflammation [9], and the blocking of apoptotic activity in malignant cells [10]

Objectives

Methods

Results

Discussion

Conclusion