Time Delay Induces Resonant Activation in Intracellular Calcium Oscillations

Abstract

The role of time delay of the active transmission processes with colored noises of the intracellular Ca^(2+) on the intracellular calcium oscillation (ICO) is investigated by means of a first-order stochastic simulation algorithm. By simulating the time series and stationary probability distribution (SPD) of the ICO system, as the time delay and colored noises increase periodicity is respectively strengthened and destroyed; bistable and monostable states appear as the time delay varies. Then, from the statistics of the mean first-passage time (MFPT) of the system from the secondary peak to the main peak of the SPD, the results indicate: as colored noises strengthen, time delay induces a resonant activation (RA) in the ICO system.