Abstract
Aim: A double blinded randomized study was designed to evaluate the time course of psychomotor, cognitive and ambulatory recovery after Propofol anesthesia and compare it to Thiopentone as induction agents.Methods: 100 patients undergoing short gynecologic procedures received either Propofol or Thiopentone for induction and nitrous oxide, oxygen and or halothane for maintenance of anesthesia. Immediate recovery (time from nitrous oxide shut off, response to pain, spontaneous eye opening, response to commands and three point orientation noted). Battery of 7 bed side psychomotor tests (Mail box, Manual dexterity, aiming, DSST, Trieger dot, pictorial recall, auditory motor coordination were recorded preoperatively and at 15 min, 30 min, 1hr, 2hr, 3hr, 4 hr postoperatively.Results: Emergence, ambulation and psychomotor recovery was significantly faster and consistent in Propofol group compared to Thiopentone. Thiopentone group was impaired even at 4 hrs, particularly at Trieger dot test and manual dexterity. Propofol group remained impaired for 1hr at mail box test, manual dexterity test and DSST and 2 hrs at Trieger dot, aiming and auditory motor coordination.
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