Abstract
Background Most animal models that elicit pulmonary allergic inflammation require a protracted sensitisation period that can last for weeks. We describe here further characterisation of a model developed by Werner-Klein and colleagues [1] that exhibits rapid and long lasting pulmonary eosinophilic infiltration requiring only a short sensitisation period. In addition, this modified rat model also exhibits a bronchoconstrictor response to allergen after a single rechallenge two weeks after the initial challenge period.
Highlights
Most animal models that elicit pulmonary allergic inflammation require a protracted sensitisation period that can last for weeks
We describe here further characterisation of a model developed by Werner-Klein and colleagues [1] that exhibits rapid and long lasting pulmonary eosinophilic infiltration requiring only a short sensitisation period
Bronchoalveolar lavage levels of granulocytes and lymphocytes were ascertained on days 6, 7, 8, 9, 11 and 15
Summary
Most animal models that elicit pulmonary allergic inflammation require a protracted sensitisation period that can last for weeks. We describe here further characterisation of a model developed by Werner-Klein and colleagues [1] that exhibits rapid and long lasting pulmonary eosinophilic infiltration requiring only a short sensitisation period. This modified rat model exhibits a bronchoconstrictor response to allergen after a single rechallenge two weeks after the initial challenge period
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