Year-end Sale % OFF 
Abstract
Prostaglandin synthesis inhibitors antagonize behavioral responses to alcohols. Recent work has shown that ethanol increases brain prostaglandin (PG) levels. The study reported here examined the tine course for ethanol-stimulated brain PGE and PGF production in Long Sleep and Short Sleep mice, animals bred selectively for high vs. low acute response to ethanol. Increases in brain PGE levels correlated highly with the absorption phase but only partially with the elimination phase of ethanol. PGF levels correlated significantly with blood ethanol levels across the entire three hour period. These results, plus sex and genotype interactions, provide further evidence to support the hypothesis that ethanol produces its intoxicating effects to a significant degree through a prostaglandin mediated mechanism.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
