Abstract
Eighty-seven patients with histologically proven cancer were given a course of 5-fluorouracil to study the effect of time of infusion and of 5% glucose in regard to toxicity and antitumor effectiveness. The over-all response rate of 25% was unrelated to time of infusion or vehicle and compares favorably with that reported for more toxic methods of administration. Beneficial effect was not dependent upon the production of systemic drug toxicity; the data suggest that, when response is slow, a significant number of patients may be forced to discontinue the drug because of toxicity before sufficient time is allowed for response. The frequency and degree of toxicity encountered with 5-FU infusions was lower than that noted following courses of undiluted drug. Infusion of 5-FU in the regimen tested seems a safe and effective method of drug administration which can be used widely on an ambulatory basis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
