Abstract
Previous studies have shown that thyroid hormones induced cytodifferentiation in immature and mature mouse submaxillary gland (SMG) and increase SMG concentrations of nerve growth factor and epidermal growth factor (EGF). These observations suggested that thyroid hormones increased SMG EGF synthesis. The following experiments were performed in order to determine the presence of specific nuclear T3 receptors in mouse SMG and the time and dose dependency of the SMG EGF response to a single injection of T3. In the first series of experiments, the presence of specific nuclear T3 receptors was established. The Ka of the receptor in SMG [0.60 ± 0.04 × 1010 M1 (mean ± SEM)] was similar to that observed in liver. The number of binding sites in SMG (46 ± 1 fmol/mg protein) was significantly less than in liver (266 ± 40 fmol/mg protein; P < 0.001). Induction of hypothyroidism in adult female mice by the administration of 0.1% propylthiouracil in their drinking water, led to a significant increase in the number of T...
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