Abstract
Abstract CD4 T cells are critical for the induction of adaptive immune responses. Surprisingly, we published a report showing that memory CD4 T cells could also mediate lethal immunopathology following chronic lymphocytic choriomeningitis virus (LCMV) infection. To interrogate whether naive or memory CD4 T cells can similarly mediate immune dysregulation, we transferred equal numbers of naive or memory virus-specific CD4 T cells into naive mice, and infected these with chronic LCMV. We found that memory CD4 T cells exhausted substantially faster than naive CD4 T cells following chronic viral infection. This downregulation of adoptively transferred memory CD4 T cells was associated with improved adaptive immune responses and survival relative to naive CD4 T cells. Our findings demonstrate the importance of inducing multiple arms of the adaptive immune response and suggest that tight regulation of memory CD4 T cells is necessary for preventing immune disease during chronic viral infection.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
