Tight-binding derivation of a discrete-continuous description of mechanochemical coupling in a molecular motor

Abstract

We present a tight-binding derivation of a discrete-continuous description of mechanochemical coupling in a molecular motor. Our derivation is based on the continuous diffusion equation for overdamped Brownian motion on a time-independent tilted periodic potential in two dimensions. The free-energy potential is nonseparable to allow coupling between the chemical and mechanical degrees of freedom. We formally discretize the chemical coordinate by expanding in Wannier states that are localized along the chemical coordinate and parametrized along the mechanical coordinate. A discrete-continuous equation is derived that is valid for anisotropic systems with weak mechanochemical coupling and deep potential wells along the chemical coordinate. The discrete-continuous description is consistent with established theoretical models of molecular motors with discrete chemical states but is constrained by the underlying continuous two-dimensional potential. In particular, we derive analytic expressions for the effective potential along the mechanical coordinate and for the rate of thermal hopping between chemical states. We determine the thermodynamic efficiency of energy conversion and find that, for a molecular motor with one chemical state per cycle, the derived discrete-continuous equation can accurately describe mechanochemical coupling but cannot describe energy conversion.