Abstract
ObjectiveTo characterize the time in therapeutic range (TTR) and estimate the incidence rate of complications (PTIRc) in adults with warfarin protocol. DesignRetrospective cohort based on medical records of patients older than 18years, between 1996 and 2016 and followed for at least three months. SiteHematology unit of a Venezuelan specialized cardiovascular center. ParticipantsElectronic health record. Main measurementsTTR and PTIRc. The variables were sex, functional illiteracy, occupation, International Normalized Ratio (INR) and follow-up time, which were analyzed with TTR and PTIRc using binomial logistic and Poisson regression models, respectively. Results2,770 patients were followed up for a total of 1,201,380 days, 42.3% had a TTR<65% and 3.5% had INR 2.5-3.5. 61.8% had complications. PTIRc was 6.84/100 person-months (95%CI: 6.56-7.15). TTR<65% showed significant adjusted OR with functional illiteracy and INR 2.5-3.5, while for higher PTIRc a significant RR was found in the two factors mentioned, shorter follow-up time, TTR<65% and in women. ConclusionsDespite new anticoagulant treatments, warfarin is useful. As follow-up time increased, control was better and the rate of occurrence of complications decreased; however, the conditions that showed lower TTR and higher rate of occurrence of complications require a thorough review of follow-up especially in patients with functional illiteracy.
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