Abstract
Lipid droplets (LDs) are dynamic organelles and involve in various physiological processes by regulation of the storage and metabolism of lipid molecules. The real-time and long-term imaging of LDs’ distribution and movement is critical for investigation of their biological functions. However, current LDs-targeted fluorescent probes suffer from low photostability and high background noise. To tackle these challenges, we herein reported that the red-emissive fluorescent probe DCQTB with twisted intramolecular charge transfer (TICT) characteristics can be used for wash-free imaging of LDs with advantages of fast cell penetration ability, high specificity, excellent photostability, and low phototoxicity. This LDs-specific fluorescent probe is thus promising for investigation of the biological functions of LDs.
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