Abstract
The tickborne fever model developed in dwarf goats and used in this study has an acute character: fever, dullness, anorexia, tachycardia, a moderate inhibition of rumen contractions, leucopenia and a decreased serum alkaline phosphatase activity. The model can be of great value in testing the therapeutic efficacy and pharmacokinetics of chemotherapeutic agents in rickettsial infections. The dwarf goats receiving oxytetracyc1ine. chloramphenicol or trimethoprim (plus sulphonamides) showed improvement, whereas ampicillin and spiramycin were ineffective. Furthermore, marked changes in drug metabolism were observed in tickborne fever-infected goats treated with chloramphenicol or sulphadimidine; the elimination half-life values of these drugs and of oxytetracycline were significantly prolonged. The pharmacokinetics of ampicillin, spiramycin and sulpha-methylphenazole did not show marked differences between healthy and tickborne fever-infected animals.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
