Abstract
Eight fatal cases of tick-borne encephalitis with unusual hemorrhagic syndrome were identified in 1999 in the Novosibirsk Region, Russia. To study these strains, we sequenced cDNA fragments of protein E gene from six archival formalin-fixed brain samples. Phylogenetic analysis showed tick-borne encephalitis variants clustered with a Far Eastern subtype (homology 94.7%) but not with the Siberian subtype (82%).
Highlights
Eight fatal cases of tick-borne encephalitis with an unusual hemorrhagic syndrome were identified in 1999 in the Novosibirsk Region, Russia
To determine the Tick-borne encephalitis virus (TBEV) genotype that probably caused the hemorrhagic form of the infection, we sequenced cDNA fragments of protein E gene
We found that the TBEV strains that most likely caused the infection with hemorrhagic syndrome carry unique mutations in protein E and belong to the Far Eastern genomic subtype
Summary
Eight fatal cases of tick-borne encephalitis with an unusual hemorrhagic syndrome were identified in 1999 in the Novosibirsk Region, Russia. Analysis of the protein E sequence of 16 European and Asian TBEV strains showed clear segregation into three genetic subtypes, designated as European, Far Eastern, and Siberian [4]. Genotyping of 75 TBEV strains typical for southern regions of Western Siberia showed that they differ considerably from European and Far Eastern strains
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