Tianchang Capsule prevents ovariectomy induced osteoporosis in rats

Huizhen Chen,Lisha Sun,Yuxi Zhu,Shan Zhou,Man Zhou,Xiaoran Zhang,Qiu Chen,Chenling Hu,Xingwang Zhao,Jia Yao,Xiaoyan Shi,Liuying Li

doi:10.1590/fst.45921

Abstract

This article performed a model of osteoporosis rats using the method of ovariectomy and observed efficacy of Tianchang Capsule on treatment of osteoporosis rats. Comparing the effect with positive drug to explore the mechanism of Tianchang Capsule in postmenopausal osteoporosis. Female SD rats were randomly assigned to 6 groups (10 in each group): control (sham-treated), OVX (by ovariectomy), OVX+AL (by ovariectomy, received alendronate sodium), OVX+LTC (by ovariectomy, received low dosage Tianchang Capsule), OVX+MTC (by ovariectomy, received middle dosage Tianchang Capsule), OVX+HTC (by ovariectomy, received high dosage Tianchang Capsule). After ovariectomy operation, alendronate or Tian Chang capsule were given for 12 weeks. Bone metabolism was measured by bone mineral density (BMD). With 12-week treatment, BMD reduced in OVX group, in bone formation and resorption parameters increased however, pathological sections indicated destruction of trabecular bone structure in the meanwhile (P < 0.05 or P < 0.01). In alendronate sodium and Tianchang Capsule treatments groups, comparing with control, both treatments significantly increased BMD level and improved the trabecular bone tissue damage, also inhibit excessive actively bone resorption and bone formation (P < 0.05 or P < 0.01). Tianchang Capsule were used as good natural drugs for the treatment of ovariectomy induced osteoporosis rats, by increasing bone mineral density, bone formation and bone resorption.

Highlights

Osteoporosis is characterized by a progressive decrease bone mass and density, result in the increase of bone fragility which lead a high risk for fragility fracture (Rachner et al, 2011)
This study will focus on the effect of Chinese medicine on postmenopausal osteoporosis, which belongs to the range of primary osteoporosis (Chinese Medical Association of Osteoporosis and Mineral Disease, 2017)
bone alkaline phosphatase (BALP) level in the group of using TC capsule decreased compared with OVX group, but there’s no statistical significance

Summary

Introduction

Osteoporosis is characterized by a progressive decrease bone mass and density, result in the increase of bone fragility which lead a high risk for fragility fracture (Rachner et al, 2011). The pathological core of osteoporosis is reducing of bone mass. The 2010 epidemic surveying date of EU shows 22 million female and 5.5 million male patients have a osteoporosis, 3.5 million of them have a fragility fracture, including hip fractures 18%, vertebral fracture 15%, forearm fracture 16%, and other types of fractures 51%. With aging of the population in worldwide, the prevalence of osteoporosis increases rapidly and it will be a huge financial burden to all the countries. Plenty of clinical experience has been accumulated in the therapy of osteoporosis with Chinese medicine, which has many advantages. This study will focus on the effect of Chinese medicine on postmenopausal osteoporosis, which belongs to the range of primary osteoporosis (Chinese Medical Association of Osteoporosis and Mineral Disease, 2017)

Objectives

Methods

Results

Conclusion