Abstract
A patient with juvenile myoclonic epilepsy (JME), manifested as absences at age 10 and myoclonic jerking and generalized tonic clonic seizures at age 15, was treated successfully with primidone at the King Fahad National Guard Hospital, Riyadh, Saudi Arabia.
Highlights
Absence seizures were provoked by thyroxine 50 meg daily prescribed at age 35 for a simple goitre associated with normal thyroid function tests
When thyroid hormone is administered in patients with epilepsy, the dose should be monitored carefully and an EEG obtained to examine for subclinical absence seizures requiring additional antiepileptic medication
A 12-year-old mentally retarded girl with a large deletion of the long arm of chromosome 21 and congenital hypothyroidism is reported from the Department of Clinical Genetics and Pediatrics, University Hospital, Uppsala, Sweden
Summary
Higher levels of T4 and TSH, consistent with a resistance to thyroid hormone, are associated with poorer attention and less hyperactive behavior in children with congenital hypothyroidism. Children with CH should be closely monitored to maintain levels of T4 and TSH within the normal range and to avoid elevations of hormone that could impede attention. Thyroxine and thyrotropin have unique effects on specific aspects of attention and behavior.
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