Abstract
ABSTRACT Serial measurements of the serum concentrations (as maximum binding capacities) of thyroxine binding prealbumin (TBPA), thyroxine binding globulin (TBG), PBI, free T4 (FT4), and percent free T4 (% FT4) were made before, during and after experimental infections (typhoid fever, tularemia and malaria) in 15 human subjects. In addition, the rate of disappearance of 125I-T4 from the circulation was determined. TBPA decreased during illness, but large initial decreases were dissociated in time from changes of FT4 and % FT4. Occasional but significant changes of TBG and PBI were unrelated to changes of TBPA and % FT4. PBI often dropped after the onset of illness, followed by a rebound which exceeded control values. These alterations of PBI alone resulted in significant FT4 changes in six cases. In two cases (malaria and shigeliosis) % FT3 changes paralleled changes of % FT4. In five subjects (two with typhoid fever and three with tularemia) increases of FT4 were not associated with any change in the rat...
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