Abstract
SummaryThyrotropin (TSH)-secreting pituitary adenomas are rare pituitary tumors that cause central hyperthyroidism by the release of TSH refractory to negative feedback regulation of thyroid hormones. The frequency of this diagnosis has increased because of the widespread availability of ultrasensitive immunometric assays for TSH and the growing awareness by clinicians of the states of inappropriate TSH secretion. The clinical presentation is varied and has been confused with more common causes of thyrotoxicosis or the syndrome of resistance to thyroid hormone. Some patients, especially those previously misdiagnosed and treated with thyroid ablation, present with signs and symptoms resulting from compression of the surrounding nervous structures by growing tumor.Failure to recognize the inappropriate secretion of TSH caused by the tumor may result in dramatic consequences, such as unnecessary thyroid ablation. In contrast, early diagnosis and correct treatment of pituitary adenomas prevent the development of complications and improve the rate of cure.
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