Abstract
Methylene—bridged thyroid hormone analogs, in which a methylene group replaces the oxygen atom bridging the two aromatic rings, were evaluated for thyromimetic activity in the rat. All five analogs tested resembled qualitatively the corresponding diphenyl ethers with respect to their ability to increase mitochondrial glycerophosphate dehydrogenase (GPD) activity in various organs and tissues. The methylene—bridged compounds exerted effects typical of the diphenyl ethers on body wt and on the wts of various organs and tissues. The methylene-bridged analogs of T4 and T3 were tested for effects upon metabolic rate and were found to increase oxygen consumption. The analog corresponding to T4 was evaluated in thyroidectomized rats and was found to elevate GPD activity, to increase oxygen consumption, and to exert T4-like effects on the wts of various organs. The methylene-bridged compounds resembled qualitatively the diphenyl ethers with respect to their ability to inhibit lipid peroxidation in vitro. Although...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
