Abstract
Objective To evaluate the effect of metformin treatment on the thyroid hormone profile in patients with polycystic ovary syndrome (PCOS). Methods A total of 148 patients with PCOS was specifically selected for either being diagnosed of hypothyroidism or subclinically hypothyroid or euthyroid without levothyroxine treatment before the starting of metformin. The serum levels of thyroid stimulating hormone (TSH) and free thyroxine (FT4) were measured before and after a 6-month period of metformin therapy. Results Thyroid function parameters did not change after starting metformin therapy in euthyroid patients with PCOS. In the 9 hypothyroid patients and 38 subclinical hypothyroid patients with PCOS, the basal median serum levels of TSH (P 0.05). Conclusions Metformin treatment has no effect on thyroid hormone, but has a TSH-lowering effect in hypothyroid and subclinically hypothyroid patients with PCOS. Key words: Metformin/TU; Polycystic ovary syndrome/DT; Thyroid gland/DE
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