Abstract
BackgroundSelenium (Se) is a necessary element for the biosynthesis of thyroid hormones. We investigated the relationship between selenium status, thyroid volume, and goiter in a cross-sectional study in an iodine-sufficient area.MethodsWe selected residents of Chengdu (over 18 years old and living in the city for more than 5 years) using a stratified cluster sampling technique. Fifteen hundred subjects were selected for the study, which involved a questionnaire survey, physical examination, thyroid ultrasound, serum thyroid function test, and determination of serum selenium level. Thyroid volume was calculated from the thickness, width, length, and a corrective factor for each lobe. Ultimately, 1,205 subjects completed the investigation and were included in our study. Additionally, 80 school-age children were selected to provide urine samples for urinary iodine analysis. We analyzed the data using appropriate nonparametric and parametric statistical tests.ResultsThe median urinary iodine value was 184 μg/L in school-age children, indicating iodine sufficiency. The median serum selenium level of the 1,205 subjects was 52.63 (interquartile range [IQR] : 40.40-67.00) μg/L. The median thyroid volume was 9.93 (IQR: 7.71-12.57) mL; both log-transformed serum selenium and log-transformed thyroid volume were Gaussian distributions (P = .638 and P = .046, respectively). The prevalences of goiter and thyroid nodules were 8.8% and 18.6%. The prevalences of positive thyroid autoantibodies, thyroperoxidase autoantibodies and thyroglobulin autoantibodies were 16.7%, 12.0%, and 11.1%, respectively. In the general linear regression model, there were positive associations between serum selenium and age, and body mass index. We found no association between serum selenium and thyroid-stimulating hormone. In simple linear regression analyses, we found no association between thyroid volume and serum selenium. There were no significant differences in serum selenium between persons with or without goiter. Serum selenium was not a risk factor for goiter.ConclusionIn our study population, serum selenium was neither associated with thyroid volume nor with goiter in an iodine-sufficient area. More studies should be conducted by following non-goitrous persons over time and monitoring their selenium status.
Highlights
Selenium (Se) is a necessary element for the biosynthesis of thyroid hormones
The antioxidant selenium protein glutathione peroxidase can protect the thyrocytes from any excess hydrogen peroxide, which is produced during thyroid hormone biosynthesis [2]
We found no association between serum thyroid stimulating hormone (TSH) and selenium concentration (Spearman correlations, r = −0.003, P = .906)
Summary
We investigated the relationship between selenium status, thyroid volume, and goiter in a cross-sectional study in an iodine-sufficient area. Both iodine and selenium are essential micronutrients for proper thyroid function. Iodine is a main component of the thyroid hormones thyroxine (T4) and triiodothyronine (T3). The trace element selenium is a component of selenocysteine and has an important role in normal thyroid hormone metabolism; it is involved in the catalysis of all known selenoenzymes (e.g., iodothyronine deiodinases and glutathione peroxidase). The antioxidant selenium protein glutathione peroxidase can protect the thyrocytes from any excess hydrogen peroxide, which is produced during thyroid hormone biosynthesis [2]
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