Abstract
ObjectivesWe assessed the analytical performance of the TSH and FT4 assays on ADVIA Centaur in a multicenter national evaluation. Design and methodsA precision study and a method comparison were performed. Reference values stated by the manufacturer were checked from 379 normal subjects. ResultsFor TSH and FT4, the intra-assay CVs were below 2.3 and 5.2%, respectively, and the inter-assay CVs below 4.4% and 7.2%, respectively. Therefore, the precision and reproducibility were acceptable. Bland–Altman bias plots revealed good correlation and agreement with Cobas assays. TSH and FT4 data yielded reference ranges of 0.64–3.24mIU/L and 10.5–18.9pmol/L, respectively. ConclusionThese assays demonstrate reliable characteristics. The reference ranges obtained can be used for interpretation of thyroid function.
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