Abstract

Objective: To study the factors in the development of atrial fibrillation in patients with subclinical hyperthyroidism on the background of angina pectoris as a result of a comprehensive analysis of the electrocardiographic and echocardiographic indicators of the heart, thyroid volume, thyroid hormone levels and lipid profile.
 Materials and Methods: The risk factors for atrial fibrillation (AF) were studied in patients with subclinical hyperthyroidism (SH) and angina pectoris. It was revealed that the starting factor for the occurrence of AF in patients with subclinical hyperthyroidism is a shift in the reference values of thyroid hormones. It was established that the total depression of the ST segment reflects the degree of coronary reserve in patients with AF on the background of SH.
 Results and Discussion: It has been shown that in patients with subclinical hyperthyroidism, there is a normal level of total cholesterol and LDLP, a low level of triglycerides and atherogenicity, and a high level of HDLP. When combined with subclinical hyperthyroidism and paroxysmal AF, there is an increase in the level of total cholesterol, LDLP, TG, atherogenicity and decreased HDLP.
 Conclusion: It has been proven that diastolic dysfunction of the left ventricle of the first type is formed on the background of SH.
 Bangladesh Journal of Medical Science Vol.18(2) 2019 p.402-410

Highlights

  • Atrial fibrillation (AF) is the most common type of tachyarrhythmia[1]

  • In numerous large studies conducted in persons older than 55-60 years, it was found that the prevalence of patients with TSH levels less than 0.1 mMED / l ranges from 0.7 to 12.4%3

  • Analysis of the literature shows that the diagnosis of the treatment of atrial fibrillation is most fully described in the manifest form of hyperthyroidism[6]

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Summary

Introduction

Atrial fibrillation (AF) is the most common type of tachyarrhythmia[1]. The prevalence of AF is from 2 to 4% in people aged 50 to 75 years, and in patients older than 75, 85, and 90 years, its prevalence is 5, 14, and 27%, respectively[2]. A comprehensive assessment of electrocardiographic and echocardiographic parameters of the heart, the thyroid status and lipid metabolism in patients with paroxysmal atrial fibrillation with a combination of subclinical hyperthyroidism was not carried out with angina. To study the factors in the development of atrial fibrillation in patients with subclinical hyperthyroidism on the background of angina pectoris as a result of a comprehensive analysis of the electrocardiographic and echocardiographic indicators of the heart, thyroid volume, thyroid hormone levels and lipid profile. The 1st group included 34 patients with asymptomatic paroxysms of AF against the background of a combination of stable angina pectoris of the II functional class with subclinical hyperthyroidism. The 2nd group included 32 patients with symptomatic paroxysmal AF on the background of a combination of stable angina pectoris of II functional class with subclinical hyperthyroidism. Lipid profile in patients with subclinical hyperthyroidism, when combined subclinical hyperthyroidism with symptomatic paroxysmal AF and subclinical hyperthyroidism with asymptomatic paroxysmal AF ( M ± m)

Subclinical hypethyroidism
Findings
Indicators ASAFAPSH SAFAPSH ASAFAP
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