Abstract
DURING the past several years there have been many investigations into the effects of either total body or local x-irradiation on various mammalian organs. In the case of the thyroid gland, however, practically all of the studies undertaken have dealt with direct irradiation of the gland by local x-irradiation (Bender, 1948; Hursh et al., 1949) or by massive doses of radioactive iodine (Goldberg et al., 1950; Gorbman, 1950). These studies have shown that in the rat local irradiation of the thyroid produces essentially no change in morphology or function of that gland until the dosage reaches 3000–6000 r, a dose which is several times the magnitude of a lethal dose of total body x-irradiation. In a brief abstract, Evans et al. (1949), reported an increased uptake of I131 by the thyroid as well as “increased activity” in the blood of rats three days after 500–1000 r total body x-irradiation.
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