Abstract
Following ligature of the main coronary veins in the rat, necrotic foci occur in the subepicardial muscle layers and massive calcification begins in the affected areas. This type of myocardial calcification—unlike the onset of necrosis—was significantly enhanced by parathyroidectomy. On the other hand, this enhancement was prevented by simultaneous thyroidectomy and could not be effected by replacement therapy with thyroxine. The alterations in the serum concentrations of calcium and inorganic phosphorus did not serve to explain the great difference in degree of myocardial calcification seen between the parathyroidectomized and thyroparathyroidectomized rats. It is postulated that some thyroid principle, apparently other than thyroxine, may be responsible for promoting the entry of various ions (such as calcium and phosphorus) into the degenerating tissue and thus may be a more important factor in the pathologic process than are variations in the levels of serum electrolytes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
