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Abstract
Thyroid Involvement in Eosinophilic Granulomatosis with Polyangiitis
Highlights
Eosinophilic granulomatosis with plyangitis (EGPA), formerly known as Allergic Granulomatous Angiitis or Churg-Straus Syndrome is a very rare necrotizing vasculitis of small and medium-sized systemic blood vessels [1,2]. It was individualized from periarteritis nodosa (PAN) by Churg and Strauss in 1951, like a systemic and pulmonary vasculitis characterized by the existence of severe asthma, blood and tissue hyper eosinophilia, associated with visceral disorders similar to those of PAN [3]
It was defined and classified according to the Chapel Hill consensus conference on the nomenclature and classification of systemic vasculitides of 1992 revised in 2012, as small and medium-sized vessel vasculitis, associating: eosinophil-rich granulomatous inflammation of respiratory tract, necrotizing systemic vasculitis, asthma, and eosinophilia [4,5]. It is an autoimmune vasculitis mediated by antineutrophil cytoplasmic antibodies (ANCA) (ANCA-associated vasculitis) [6]
Endocrine damage that of the thyroid gland, are exceptional during systemic vasculitis [8,9,10,11,12,13]. They raise the problem of their mechanism, As well as that of their treatment and prognostic implications [8,9,10,11,12,13]
Summary
Eosinophilic granulomatosis with plyangitis (EGPA), formerly known as Allergic Granulomatous Angiitis or Churg-Straus Syndrome is a very rare necrotizing vasculitis of small and medium-sized systemic blood vessels [1,2]. It was individualized from periarteritis nodosa (PAN) by Churg and Strauss in 1951, like a systemic and pulmonary vasculitis characterized by the existence of severe asthma, blood and tissue hyper eosinophilia, associated with visceral disorders similar to those of PAN [3]. It was defined and classified according to the Chapel Hill consensus conference on the nomenclature and classification of systemic vasculitides of 1992 revised in 2012, as small and medium-sized vessel vasculitis, associating: eosinophil-rich granulomatous inflammation of respiratory tract, necrotizing systemic vasculitis, asthma, and eosinophilia [4,5].
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