Abstract
Type 1 diabetes (T1D) in the child population is the third most common chronic disease. Diabetic peripheral neuropathy (DPN) is a very disabling and silently developing complication. This prospective, observational study enrolled 182 (93 girls) patients with T1D, aged 16.5–18 years. The aim of the study was to assess the correlation between factors of diabetes metabolic control, blood count, thyroid hormones, thyroid-stimulating hormone (TSH), level of cortisol, vitamin D3, metabolic factors, demographic data, and nerve conduction study (NCS) parameters. We revealed that in multivariate regression models for almost all NCS parameters, beside height and diabetes duration, significant factors were basal insulin dose per kilogram of weight (BID/kg), body mass index (BMI), and thyroid hormones. For conduction velocities of the motor nerves, mean HbA1c exists in models. In all models for all NCS parameters there exists at least one parameter of peripheral white blood cell counts (predominantly monocytes). There is a significant influence of thyroid hormones, peripheral blood white cells count, and BID per weight on parameters of NCS. It is essential to take care of the proper insulin dose per weight of patients and the adequate proportion of basal to prandial insulin.
Highlights
Type 1 diabetes (T1D) in the child population is the third most common chronic disease, and its incidence is still increasing
We revealed that in models, there are correlations between almost all nerve conduction parameters and demographic factors like height and diabetes duration, basal daily dose per kilogram of weight, body mass index (BMI), and thyroid hormone
For conduction velocities of the motor nerves, mean hemoglobin A1c (HbA1c) exists in models
Summary
Type 1 diabetes (T1D) in the child population is the third most common chronic disease, and its incidence is still increasing. Diabetic peripheral neuropathy (DPN) is a very disabling and silently developing complication. The lack of effective treatment for DPN highlights the importance of early diagnosis to prevent progression. DPN is the presence of symptoms and/or signs of peripheral nerve dysfunction caused by diabetes. DPN is often asymptomatic; once symptoms and overt deficits have developed, it cannot be reversed. Children rarely develop symptoms of DPN; consequences of DPN are foot ulceration which can lead to amputation or chronic pain. Early prevention and detection are crucial to curb the progression of DPN in children
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
