Abstract
Objectives: To assess thyroid hormones pattern in preeclampsia in third trimester, in our Pakistani population (Punjab). Methods| It was a Comparative cross- sectional study. Thyroid hormones; namely thyrotropin (TSH), Total triiodothyronine (tT3), free triiodothyronine (fT3), Total thyroxine (tT4) and free thyroxine (fT4) were evaluated by enzyme linked immunoassay (ELISA) in 17 diagnosed preeclamptic subjects with 16 number of matched normotensive pregnant subjects. Data was entered in the form of a questionnaire and analyzed by using version SPSS 17. Results| In this study the mean TSH concentration was 100% higher in preeclamptic subjects as compared to normotensive pregnant subjects, whereas Mean of tT3, tT4, fT3 and fT4were lower when compared between healthy normotensive pregnant and preeclamptic women but no significant difference was seen between both the groups. Conclusion| This study shows statistically non-significant increase in TSH levels and decrease in total and free T3 and T4 levels of PE as compared to the normotensive pregnant subjects.
Highlights
Modifications in thyroid hormones during gestation are well-documented; information regarding adaptation of thyroid function in pre-eclampsia (PE) is scanty
Patients with known history of chronic hypertension, renal disorders, cardiovascular diseases, diabetes, any metabolic disorder that may threat to mother or fetus and history of any treatment that might disturb the thyroid function were excluded from the study
This study shows the comparison of thyroid hormones between healthy normotensive pregnant and preeclamptic women
Summary
Modifications in thyroid hormones during gestation are well-documented; information regarding adaptation of thyroid function in pre-eclampsia (PE) is scanty. Pre-eclampsia, called toxemia of gestation, was established according to American college of obstetrics and gynecology (ACOG), After the 20th weeks of pregnancy a blood pressure of more than 140/90 mm Hg and proteinuria higher than 300mg/24hr were detected on at least two occasions more than 6hrs apart.[1] PE is a multisystem disorder of the pregnancy that affects the fetus because of placental dysfunction.[2] These fetuses are at the threat of premature delivery and intra-uterine growth retardation.[3]. PE women have high occurrence of hypothyroidism that might correlate with the severity of PE. The high circulating estrogen levels during the gestation are accounted for fluctuations in thyroid function.[8]
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