Abstract
The effects of cell swelling induced by hyposmotic shock on efflux of thyroid hormones and selected amino acids from human placental tissue were examined. Decreasing the osmolarity of external medium from 290 to 140 mOsm/kg stimulated release of taurine, tryptophan and glutamine from placental tissue fragments. The efflux rate constant for taurine increased from 0.0069 ± 0.0012/min to 0.0646 ± 0.0217/min ( n=6) ( P<0.001), for tryptophan from 0.0116 ± 0.0010/min to 0.0295 ± 0.0016/ min ( n=6) ( P<0.001), and for glutamine from 0.0267 ±E0.0027/min to 0.0659 ±00.0043/min ( n=4) ( P<0.001). In contrast, hyposmotic challenge did not affect release of triiodothyronine, thyroxine and leucine. These results indicate that transport processes involved in the regulation of cellular volume are unlikely to facilitate efflux of thyroid hormones from placental tissue, and therefore are unlikely to mediate transfer of thyroid hormones across the placenta. In addition, it is unlikely that the transport system facilitating the release of amino acids from placental tissue during regulatory volume decrease is one of the known amino acid carriers.
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