Thyroid hormone decreasing after mechanical thrombectomy for cerebral infarction (P3-5.018)

Abstract

<h3>Objective:</h3> The aim of this study wasto clarify the changes in thyroid hormone levels in the acute phase and the effects of the iodine contrast agent on thesehormones. <h3>Background:</h3> Mechanical thrombectomy (MT) is an established treatment for large vessel occlusion in patients with cerebral infarction. The use of iodine contrast agent decreases thyroid hormone levels via the so-called Wolff-Chaikoff effect. Low triiodothyronine (T3) syndrome caused by a severe illness status can contribute to decreased thyroid hormones. Reportedly, a low T3 level is associated with poor prognosis in patients with cerebral infarction. <h3>Design/Methods:</h3> This was a single-center, prospective, and single-arm trial. Thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) were tested on admission and 24 h postoperatively in patients who were approved for MT. <h3>Results:</h3> A total of 37 patients were screened during the study period and 31 patients were enrolled. Significant decreases were observed in TSH (<i>P</i> &lt; 0.001) and FT3 (<i>P</i> &lt; 0.001) levels 24 h after MT. Moreover, there was a correlation between the decrease ratio of change in FT3 levels and the amount of iodine contrast agent used per body surface area (<i>r</i> = 0.43, <i>P</i> = 0.019), while no such correlations were detected for TSH and FT4. <h3>Conclusions:</h3> We demonstrated that decrease in TSH and FT3 levels in the acute phase after MT and that FT3 levels were associated with the amount of iodine contrast agent used. <b>Disclosure:</b> Dr. Kobayashi has nothing to disclose.