Abstract
WCN 2013 No: 300 Topic: 3 — Stroke Thyroid hormone contributes to hippocampal neural progenitor cell proliferation in adult 2vo rats L. Ting, B. Chisulo, Q. Wang. Neurology, Nanfang Hospital, Guangzhou, China; Medicine, Kitwe Central Hospital, Kitwe, Zambia Background: Thyroid hormone (TH) plays a critical role in developing the nervous system and regulating proliferation, survival and differentiation of neural progenitor cells. Hypothyroidism decreases the survival and differentiation of adult dentate granule cell progenitors. Objective: To investigate the effects of TH on proliferation of stem cells in the hippocampal subgranular zone (SGZ). Materials andmethods:Weachieved vascular cognitive impairment in animal model by permanent bilateral occlusion of common carotid arteries, set interventions of thyroid hormone treatment, and observe the effect on proliferation of adult dentate granule cell progenitors after chronic cerebral ischemia by immunofluorescence staining method. Rats were administered with T3 (10 mg/30 g·d) for 7 d or a single T3 (10 mg/30 g) after ischemia, and same dose of saline in control animals. Neurogenesis was studied by Bromodeoxyuridine (BrdU) immunohistochemistry in the SGZ. Results: T3 treatment for 7 d after ischemia increased the number of BrdU cells in the SGZ compared to saline (p = 0.005, p b 0.001, respectively). A single T3 injection 10 h before death also enhanced proliferation in SGZ 7d after chronic cerebral ischemia compared to saline (p = 0.015, p b 0.001, respectively). Conclusion: The results suggest that T3 enhance ischemia-induced proliferation of hippocampal in adult rats, and a short T3 influence on mitotic activity suggested T3 may act directly on progenitor cell populations. doi:10.1016/j.jns.2013.07.666 Abstract — WCN 2013 No: 301 Topic: 3 — Stroke The CHA2DS2-VASc score reflects clinical outcomes in NVAF patients with an initial cardioembolic stroke WCN 2013 No: 301 Topic: 3 — Stroke The CHA2DS2-VASc score reflects clinical outcomes in NVAF patients with an initial cardioembolic stroke I. Deguchi, T. Hayashi, Y. Ohe, Y. Kato, T. Fukuoka, H. Maruyama, Y. Horiuchi, H. Sano, Y. Nagamine, N. Tanahashi. Department of Neurology, Saitama Medical University International Medical Center,
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