Abstract
This study investigated if free T4 and TSH concentrations or thyroid function categories were associated with prevalent CHD and the severity of coronary atherosclerosis in a population undergoing coronary angiography. This was a cross-sectional study including 1799 patients who were consecutively admitted and underwent coronary angiography. We evaluated the severity of coronary atherosclerosis using Gensini score. In the entire study population, free T4 level was inversely associated with prevalent CHD (OR = 0.95, 95% CI 0.91–0.99, P = 0.01) and the natural log-transformed Gensini score (ln(Gensini score)) (β = −0.03, 95% CI −0.05–−0.01, P = 0.005). The odds of CHD increased gradually across hyperthyroidism, subclinical hypothyroidism, and overt hypothyroidism groups using the euthyroid group as the reference, and the trend is borderline significant (P for trend = 0.051). When comparing to the euthyroid group, ln(Gensini score) of the overt hypothyroidism group was significantly higher (P = 0.009), but the trend was not significant (P for trend = 0.08). A significant association of thyroid function with CHD or ln(Gensini score) in euthyroid patients was not observed. The present study demonstrated an association of thyroid function with prevalent CHD and the severity of coronary atherosclerosis in a population undergoing coronary angiography. However, this association was not observed in euthyroid individuals.
Highlights
Thyroid hormone has many effects on the cardiovascular system [1]
Using the data from patients who were consecutively admitted to the Department of Cardiology and underwent coronary angiography, we investigated if free T4 and thyroid stimulating hormone (TSH) concentrations were associated with prevalent coronary heart disease (CHD) and the severity of coronary atherosclerosis and examined the relationship between thyroid function categories and prevalent CHD and the severity of coronary atherosclerosis in the entire study population and in euthyroid individuals
The levels of total cholesterol, low density lipoprotein (LDL)-C, and triglyceride were similar between CHD and non-CHD groups, but the high density lipoprotein cholesterol (HDL-C) level was lower in the CHD group
Summary
Thyroid hormone has many effects on the cardiovascular system [1]. Thyroid dysfunction results in changes in cardiac contractility, cardiac output, myocardial oxygen consumption, systemic vascular resistance, and blood pressure [1, 2]. The relationship between abnormal thyroid function and coronary heart disease (CHD) has been recognized for a long time, especially in hypothyroidism status due to the associated hypercholesterolemia and hypertension [3, 4]. Even subclinical hypothyroidism [5] and subclinical hyperthyroidism [6] have been related to increased risk of CHD and mortality, still controversial [7, 8]
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