Abstract
Thyroid-function studies were performed in 12 patients with active acromegaly. 1 patient had thyrotoxicosis, the rest were considered euthyroid although 3 of them had abnormal thyroid scans. All patients had a normal serum thyroid-stimulating-hormone (T.S.H.) level. The euthyroid group had renal and thyroid iodide clearances significantly greater than normal (P < 0·05 and P < 0·01 respectively). The absolute iodide uptake (A.I.U.) and 21/2-hour radioiodine uptake by the thyroid were also significantly greater than normal (P<0·05) and the plasma-inorganic-iodide (P.I.I.) was in the low normal range. The maximal binding capacity of thyroxine-binding prealbumin (T.B.P.A.) was increased and the maximal binding capacity of thyroxine-binding globulin (T.B.G.) was normal during the early years of active acromegaly. However, considering the duration of active disease (range 4-30 years) a significant linear diminution (P < 0·05) of both T.B.P.A. and T.B.G. could be demonstrated with time.
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