Abstract
Background and objectiveCoronavirus disease 2019 (COVID-19) is an on-going epidemic with a multitude of long-ranging effects on the physiological balance of the human body. It can cause several effects on thyroid functions as well. We aimed to assess the lasting sequelae of COVID-19 on thyroid hormone and the clinical course of the disease as a result.MethodsOut of 76 patients, 48 patients of COVID-19 positive and 28 patients of COVID-19 negative polymerase chain reaction (PCR) were assessed for thyroid functions, IL-6, and Procalcitonin between moderate, severe, and critical pneumonia on HRCT.ResultsSeventy-five percent of patients with COVID-19 had thyroid abnormalities and higher IL-6 levels (76.10 ± 82.35 vs. 6.99 ± 3.99, 95% CI 52.18–100.01, P-value <0.01). Logistic regression analysis suggested TT3 (P-value 0.01), IL-6 (P-value <0.01), and Procalcitonin (P-value 0.03) as independent risk factors for COVID-19. ROC curve demonstrated IL-6 as the most sensitive marker (P-value <0.01), and TT3, and Procalcitonin as the predictor for COVID-19 disease.ConclusionThis pilot study from Pakistan demonstrates that changes in serum TSH and TT3 levels may be important manifestations of the courses of COVID-19 pneumonia.
Highlights
The on-going pandemic of coronavirus disease 2019 (COVID-19) has been found to have multiple long-ranging effects on the normal physiological balance of the human body
Seventy-five percent of patients with COVID-19 had thyroid abnormalities and higher IL-6 levels (76.10 ± 82.35 vs. 6.99 ± 3.99, 95% Confidence interval (CI) 52.18–100.01, P-value
receiver operating characteristic (ROC) curve demonstrated IL-6 as the most sensitive marker (P-value
Summary
The on-going pandemic of coronavirus disease 2019 (COVID-19) has been found to have multiple long-ranging effects on the normal physiological balance of the human body. Complex and severe effects on human organ systems are being identified rapidly, including the respiratory, gastric, circulatory, immune, renal, hepatic, cardiac, and hematological systems. Coronavirus disease 2019 (COVID-19) is an on-going epidemic with a multitude of longranging effects on the physiological balance of the human body. It can cause several effects on thyroid functions as well. We aimed to assess the lasting sequelae of COVID-19 on thyroid hormone and the clinical course of the disease as a result. Editor: Sun Young Lee, Boston University School of Medicine, UNITED STATES
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