Abstract
Background and objectivesThe association between thyroid dysfunction and supraventricular tachyarrhythmia (SVT) other than atrial fibrillation (AF) is not well elucidated. We hypothesized that patients with suspected or documented SVT have undetected thyroid dysfunction more frequently than general population.Subjects and methodsPatients with symptoms suggestive of SVT other than AF who were planned to undergo an EP study at our center were eligible for this study. Patients with known thyroid disease, medications affecting thyroid function test (TFT) or atrial fibrillation were excluded. The primary outcome was prevalence of TFT abnormalities in the study population. The secondary outcome was prevalence of clinically significant arrhythmia during the EP study.ResultsA total of 533 patients were analyzed. Patients were divided into the two groups according to TFT results. Fifty-six (10.5%) patients had abnormal TFT results (thyroid dysfunction group), while 477 (89.5%) had normal thyroid function (euthyroidism group). The overall prevalence of thyroid dysfunction was 10.5%. The thyroid dysfunction group showed a tendency for higher induction of clinically significant SVT than the euthyroidism group. However, thyroid dysfunction was not an independent predictor of clinically significant SVT during EP study.ConclusionIn this study, patients with suspected SVT who were planned for EP study had a relatively high incidence of thyroid dysfunction. Clinically significant arrhythmia tended to be induced more frequently in the thyroid dysfunction group than in the euthyroidism group. Further investigations are needed to verify the clinical implications of TFT in patients with SVT other than AF.
Highlights
Many people experience palpitations at some point in their lives
The thyroid dysfunction group showed a tendency for higher induction of clinically significant supraventricular tachyarrhythmia (SVT) than the euthyroidism group
In this study, patients with suspected SVT who were planned for EP study had a relatively high inci‐ dence of thyroid dysfunction
Summary
Many people experience palpitations at some point in their lives. Palpitations, are not always due to an arrhythmia, and not all arrhythmias result in palpitations. While some patients are diagnosed by electrocardiogram, others only have symptoms of arrhythmias. Electrophysiology (EP) studies help to elucidate the presence or mechanism of arrhythmia in these patients. Hyperthyroidism, can cause palpitations, which are one of the common symptoms of thyroid disease [1]. A recent guideline recommends the evaluation of thyroid function in AF patients [2,3,4]. Supraventricular tachyarrhythmias (SVT) other than AF are a common cause of palpitations, the association of non-AF SVTs and thyroid dysfunction has not been well elucidated. The current guidelines recommend ruling out hyperthyroidism in cases of inappropriate sinus tachycardia or premature extra beats [5, 6]. The association between thyroid dysfunction and supraventricular tachyarrhythmia (SVT) other than atrial fibrillation (AF) is not well elucidated. We hypothesized that patients with suspected or docu‐ mented SVT have undetected thyroid dysfunction more frequently than general population
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