Abstract
Background: The rate of thyroid disorders is reported to be increased in patients with Ulcerative Colitis (UC) and Crohn’s disease (CD) than the normal population. The purpose of this study is to evaluate the prevalance of Thyroid disorders in a group of patients with inflammatory bowel diseases (IBD). Material and Methods: 146 IBD patients (113 UC and 33 CD patients) and 66 healthy control subjects were enrolled into the study. Serum free T4 (FT4), free T3 (FT3), TSH and anti TPO levels of the patients were analyzed retrospectively and and compared with a control group. These cases were also investigated with thyroid ultrasound and nuclear (scintigraphy) imaging. Results: The mean age of IBD patients (76 women) was 42.9 ± 12.4 years. Among the control group 42 were female and their mean age was 40.9 ± 12.1 years. Thyroid gland disease was found in 14 (9.5%, 8 female, 6 male) of 146 IBD patients. The frequency of thyroid disorders has been found to be higher than the control group in patients with control group (14/146 vs. 1/66, p = 0.042). No statistically significant difference has been observed at the thyroid disorder rates between the UC and CD patients (11/113 vs. 3/33, p = 0.912). Hashimoto thyroiditis has been found at 4 (2.7%) of the IBD patients. Conclusion: In accordance with several works published in literature, we have found a higher rate of thyroid disease apperance at IBD patients.
Highlights
Inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn’s disease (CD) are diseases that is caused by dysregulation of immune system in patients with genetic predisposition and characterized by chronic inflammation with relapse and remission periods
When mean fT3 fT4 and TSH levels are taken into consideration, no significant difference was observed between the inflammatory bowel diseases (IBD) patients and the control group
The frequency of Hashimoto thyroiditis was similar in IBD patients and in the control group (2.7% vs. 1.5%, p = 0.596)
Summary
Inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn’s disease (CD) are diseases that is caused by dysregulation of immune system in patients with genetic predisposition and characterized by chronic inflammation with relapse and remission periods. The rate of thyroid diseases is reported to be higher in UC and CD patients compared to normal population [3,4,5]. The aim of this study was to evaluate the prevalance of thyroid disorders in patients with UC and CD. The rate of thyroid disorders is reported to be increased in patients with Ulcerative Colitis (UC) and Crohn’s disease (CD) than the normal population. The purpose of this study is to evaluate the prevalance of Thyroid disorders in a group of patients with inflammatory bowel diseases (IBD). Serum free T4 (FT4), free T3 (FT3), TSH and anti TPO levels of the patients were analyzed retrospectively and and compared with a control group These cases were investigated with thyroid ultrasound and nuclear (scintigraphy) imaging. Conclusion: In accordance with several works published in literature, we have found a higher rate of thyroid disease apperance at IBD patients
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