Thyroid crisis subsequent to withdrawal of propylthiouracil.

Abstract

Case Reports1 June 1954THYROID CRISIS SUBSEQUENT TO WITHDRAWAL OF PROPYLTHIOURACILTHOMAS R. KELLY, M.D., THEODORE L. BLISS, M.D., F.A.C.P.THOMAS R. KELLY, M.D.Search for more papers by this author, THEODORE L. BLISS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-40-6-1223 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe occurrence of a fulminating and fatal thyroid crisis subsequent to the withdrawal of propylthiouracil used to control hyperthyroidism is the basis of this report. The thyroid-blocking drugs have gained wide acceptance as a preparation for surgery and as a definitive method of treating hyperthyroidism. In the latter use its withdrawal may be followed by relapse after variable intervals. We were unable to find a report of thyroid crisis occurring at an interval subsequent to the withdrawal of a thyroid-blocking drug. Nelson et al.1have reported death due to thyroid crisis a few days after the administration of radioactive iodine...Bibliography1. NelsonCavenaghBernstein RBSBA: A case of fatal thyroid crisis occurring after radioactive iodine therapy, Illinois M. J. 101: 265-267, 1952. MedlineGoogle Scholar2. Pollard AB: Fatal thyroid crisis complicating toxic granulopenia during thiouracil therapy, Lancet 1: 388-389, 1951. CrossrefMedlineGoogle Scholar3. McArthurMeansRawsonCope JWJHRWO: Thyrotoxic crisis, J. A. M. A. 134: 868-874, 1947. CrossrefMedlineGoogle Scholar4. Levy RL: Effect of thyroid secretions on action of adrenalin, Am. J. Physiol. 41: 492-511, 1916. CrossrefGoogle Scholar5. Kuriyama S: Influence of thyroid feeding upon carbohydrate metabolism, Am. J. Physiol. 43: 481-496, 1917. CrossrefGoogle Scholar6. Haban G: Leberveranderungen, bei experimentellem Hyperthyreodismus, Beitr. z. path. Anat. u. z. allg. Path. 95: 573-589, 1935. Google Scholar7. Lahey FH: Reduction of mortality in hyperthyroidism, New England J. Med. 213: 475-479, 1935. CrossrefGoogle Scholar8. FicarraNaclerio BJEA: Thyroid crisis, Am. J. Surg. 69: 325-335, 1945. CrossrefGoogle Scholar9. Lahey FH: Acute hyperthyroidism, New York State J. Med. 33: 857-863, 1933. Google Scholar10. MaddockPedersenColler WGSFA: Studies of blood chemistry in thyroid crisis, J. A. M. A. 109: 2130-2135, 1937. CrossrefGoogle Scholar11. Holman EF: Hypoglycemia in exophthalmic goitre, Johns Hopkins Hosp. Bull. 34: 69-70, 1923. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Akron, Ohio*Received for publication October 9, 1953.†We are indebted to Dr. John E. Howard for a transcript of that record. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDisorders of General FeelingsEndocrine Emergencies (Nondiabetic)A CLINICAL STUDY OF THYROID STORM*†SHELDON S. WALDSTEIN, M.D., SHELDON J. SLODKI, M.D., G. IRENE KAGANIEC, M.D., DAVID BRONSKY, M.D. 1 June 1954Volume 40, Issue 6Page: 1223-1226KeywordsDrugsHyperthyroidismSurgeryThyroid Issue Published: 1 June 1954 PDF downloadLoading ...