Abstract
PurposeSevere acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is challenging health systems all over the world. Cancer patients have a higher risk of being infected by SARS-Cov-2 and higher coronavirus disease 2019 (COVID-19) severity and mortality. Up to date, there were no data about COVID-19 in patients with thyroid cancer (TCs). The aim of the study was to describe the prevalence of COVID-19 in a well-characterized series of TC patients evaluated for the persistence of the neoplastic disease from March to September 2020; as secondary objective, we looked for the COVID-19 disease severity in a subgroup of multimetastatic TC patients.MethodsWe evaluated 1464 patients affected by persistent TC: 67 patients who were taking multikinase inhibitors (MKIs) and 1397 under active surveillance for a persistent but stable disease. During the clinical evaluation, all patients were specifically investigated about a positive history of Sars-Cov-2 infection.ResultsSARS-Cov-2 infection was identified in 4/1464 (0.3%) cases of patients affected by TC. We identified three cases among patients under active surveillance (0.2%), and one case among patients treated with MKI systemic therapy (1/67, 1.5%). This patient was taking vandetanib for metastatic medullary thyroid cancer (MTC), when he came to our attention referring severe fatigue, dyspnea for light physical activities. He presented a mild COVID-19 and he received exclusively supportive care. After a multidisciplinary consultation, we decided against the discontinuation of vandetanib. After 2 months from the infection, he did not present any signs of active infection, and the MTC metastatic disease was stable.ConclusionsWe showed that COVID-19 is not more frequent in TC patients than in general population, although a relatively higher prevalence in the group of TC patients treated with MKIs. A single patient with advanced TC and SARS-Cov-2 infection during MKIs treatment had a mild COVID-19 and did not require the discontinuation of MKI therapy. In cases of more severe COVID-19, an accurate evaluation from a multidisciplinary team would consider risks and benefits in taking the decision to continue or stop MKI treatment.
Highlights
On March 11, 2020, severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection outbreak was Cancer patients are vulnerable patients, mostly due to their multiple comorbidities
After 6 months from the begin of COVID-19 pandemic in Italy, we investigated the impact of COVID-19 in patients with thyroid cancer (TC) with particular regard to those with an advanced and multimetastatic disease who were taking multikinase inhibitors (MKIs) as systemic antineoplastic therapy
We discovered 4/1464 (0.3%) cases of patients affected by TC who had SARS-Cov-2 infection
Summary
On March 11, 2020, severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection outbreak was Cancer patients are vulnerable patients, mostly due to their multiple comorbidities. Hypertension, Endocrine (2021) 72:332–339 chronic obstructive pulmonary disease, and diabetes were the most frequent diseases in cancer patients [3], and, in the other hand, all of them were related to a higher risk of mortality in patients affected by COVID-19 [2, 4,5,6]. According to their “frail” status, neoplastic patients demonstrated to have higher risk of being infected by SARS-Cov-2 [7]. Neoplastic patients with active/progressive diseases presented higher risk of mortality [9], the impact of anticancer therapies on COVID-19 mortality was questioned by many clinicians
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