Abstract

Interest has been directed to the relationship between depressive disorders and thyroid axis function for many years. In the past 20 years, numerous studies have examined various indices of thyroid axis function in patients with depressive disorders and effects of thyroid axis hormones on mood and behavior. A third line of interest has involved effects of various psychotropic drugs used in the treatment of affective disorders on thyroid axis function. The major focus of this chapter will be on studies examining the interaction between the thyroid axis and depression. However, we start with a brief overview of reasons for interest in a role of the thyroid axis in depression.

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