Abstract
Antigenic structure remains a major focus in thyroid immunology. The genes for three major thyroid antigens—thyroglobulin, thyroid peroxidase and the thyrotropin receptor—were sequenced in the late 1980's, and epitopes for antibody and T cells have been reported within the last year. In addition, new evidence for selective use of T-cell receptor V gene segments in human thyroid infiltrates may point the way to specific immunotherapy.
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