Abstract
This chapter discusses thyroid and antithyroid drugs. The management of hyperthyroidism in pregnancy is discussed in detail. The use of low doses of antithyroid drugs is considered which recalls the danger of propranolol in pregnancy. Treatment of lactating mothers with antithyroid drugs has been thought to be contraindicated owing to a potential antithyroid effect on the infant. Iodine deficiency is increasingly recognized as a potential hazard during pre-and perinatal life, especially since it retards fetal brain development. Administration of iodized oil to mothers living in an iodine-deficient area has significant beneficial effects on the mental development of children born to these mothers. Incautious iodine administration to pregnant mothers, however, seems to be a serious potential hazard. Iodine readily crosses the placenta and, when present in excess, may induce goiter and even hypothyroidism. These congenital goiters may be sufficiently large to cause potentially fatal respiratory distress.
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