Abstract
THE role of iodine-131 in the possible development of thyroid tumours has been a matter of considerable concern in view of its widespread clinical use. The occurrence of thyroid tumours in rats after single-dose administration of iodine-131 has been described by Goldberg and Chaikoff1; but no reports of such tumour development in other species have been recorded. During the course of an extended investigation of the effects of iodine-131 administered daily to sheep2,3, thyroid adenomas were encountered in four of a group of five sheep which were exposed to 5 µc. iodine-131 per day for their lifetime. The development of a fibrosarcoma in the thyroid region of the remaining member of this group is reported separately4.
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