Abstract
To investigate the relation between the hypocalcemic activity of thyrocalcitonin and the rate of bone resorption, the quantitative effect of exogenous thyrocalcitonin was studied in rats in which the rate of bone resorption was altered by thyroparathyroidectomy and by the administration of calcium salts, parathyroid extract or vitamin D3. In sham-operated rats made hypercalcemic by the oral administration of CaCl3, thyrocalcitonin had no significant hypocalcemic activity. In thyroparathyroidectomized rats given oral CaCl2, a full Hypocalcemic response to thyrocalcitonin, of 1.49 mEq/1, occurred. In sham-operated and thyroparathyroidectomized rats made hypercalcemic by the administration of parathyroid extract, thyrocalcitonin caused mean decreases in the plasma concentration of calcium of 0.83 and 1.47 mEq/1, respectively. In hypercalcemia produced by the administration of a single dose of 105 USP U of vitamin D3, sham-operated and thyroparathyroidectomized rats showed mean decreases in the plasma concent...
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