Abstract
SUMMARY In rats in which arthritis had been induced by injections of formalin, removal of the thymus led to slight aggravation of the disease. Cortisone, which prevented or arrested the arthritis in intact rats, produced serious aggravation of the condition in thymectomized animals. The action of the thymus is not apparently hormonal but depends on the presence of thymic tissue. It seems that this phenomenon is connected with the participation of the thymus in polysaccharide metabolism. The various manifestations and the mechanism of thymic action are discussed, and a theory is put forward to explain the mechanism of action of cortisone.
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