Thymosin alpha 1 provides short-term and long-term benefits in the reimplantation of avulsed teeth: a double-blind randomized control pilot study

Abstract

Background This study investigates the short-term and long-term effects of thymosin alpha 1 (Talpha1) on reimplantation of avulsed teeth. Methods and Material Seventy-three patients with avulsed teeth were double-blind randomly assigned to a control group and group that used Talpha1. The teeth were reimplanted after treatment with Talpha1 or saline. Patients were monitored for both short-term and long-term parameters. Results The thymosin group demonstrated a lower interferon, tumor necrosis factor α and interleukin-6 levels ( P < .05) and higher white blood cell levels than the control group ( P < .05). The thymosin group demonstrated greater periodontal healing ( P < .05), less ankylosis ( P < .05), less tooth movement, and greater lifetime of the replanted teeth. Conclusion The use of Talpha1 has both short-term and long-term beneficial effects during reimplantation of avulsed teeth.