Abstract
The effects of thymosin α 1 (Tα 1) on mammary carcinogenesis was investigated in Fisher rats. Mammary carcinomas were observed 3 months after N-nitrosomethylurea (NMU) injection (10 mg, i.p.) into Fisher rats. Daily administration of Tα 1 (10 μg, s.c.) reduced mammary carcinoma incidence and prolonged survival time. Animals treated with exogenous Tα 1 had a significantly greater blood white cell density than control Fisher rats. These results suggest that Tα 1 prevents mammary carcinoma incidence as a result of stimulation of the immune system.
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