Abstract
Background: Cisplatin (CPN) is widely used for the management of various malignant tumors. Objectives: This study investigated the effects of Thymoquinone (TQN) on the expression of the p62 gene in CPN-induced testicular damage in mice. Methods: Histomorphometry, testis injury scores, expression of p62, and protein levels of LC3-II were assessed. Results: Cisplatin induced histological changes, increased p62 expression (P < 0.01), and reduced LC3-II levels (P < 0.001). Thymoquinone pretreatment decreased p62 expression while increasing LC3-II protein levels. Thymoquinone significantly reversed the testicular injury scores and improved histomorphometric parameters. Conclusions: The results indicate that TQN enhances autophagy and improves testicular tissue in CPN-intoxicated mice.
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