Abstract
Recently, we read with great interest the article “ Th ymidylate synthase polymorphisms and hematological cancer risk: a meta-analysis ” when it was published online in Leukemia and Lymphoma [1], which reached important conclusions about the association between two polymorphisms (TSER and 1494del6) in the thymidylate synthase (TYMS) gene and hematological cancer risk. Th rough quantitative analysis, this meta-analysis suggests that the TSER polymorphism may contribute to susceptibility to acute lymphoblastic leukemia (ALL) in children (3R/3R vs. 2R/2R: odds ratio [OR] 1.46, 95% confi dence interval [CI] 1.03 – 2.06) and non-Hodgkin lymphoma (NHL) in Caucasians (2R/3R vs. 2R/2R: OR 1.31, 95% CI 1.10 – 1.56) but protection from ALL risk in adults (2R/3R vs. 2R/2R: OR 0.64, 95% CI 0.43 – 0.97). In addition, the results show that the TS and 3′ -untranslated region (UTR) 1494del6 polymorphism may have a protective effect on
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