Abstract

Recently, two distinct isoforms of thymic stromal lymphopoietin(TSLP) have been discovered with opposing functions. The long form(lfTSLP) upregulates Th2 inflammation. The short form(sfTSLP) is constitutively expressed in healthy lung, skin, and intestinal tissue and has anti-inflammatory properties. Differential expression of the isoforms has been implicated in atopic dermatitis and asthma, with increased lfTSLP in relation to sfTSLP in the epithelial cells of the skin and lung, respectively. However, this has not been investigated in eosinophilic esophagitis(EoE).

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