THU351 Reduced Total Antixoxidant Capacity In Type 1 DM Without Chronic Complications

Abstract

Abstract Disclosure: S.C. Oliveira: None. C.S. Oliveira: None. C.S. Stein: None. M.W. Lauria: None. R.N. Moresco: None. F.V. Comim: None. M.O. Premaor: None. Type 1 diabetes mellitus (T1DM) is a condition associated with chronic inflammation and disturbances in the oxidative stress balance, which may be related to its complications. Our study aimed to investigate some REDOX markers ( TOS=total oxidant status ; TAC= total antioxidant capacity; FRAP =ferric reducing ability of plasma; AOPP=advanced oxidation protein products) in subjects with type 1 diabetes and controls. The local ethics committee approved this study. Overall, 51 subjects with T1DM and 106 controls were evaluated in an outpatient clinic. The age in T1DM group was (mean +− SD) 43.7 +− 17 years versus 43.1 +− 13.5 years in controls (NS).The proportion of smokers (17% vs. 15%) and ethnic composition were comparable between the groups. The mean +− SD HbA1c was 8.15 +− 1.65 % in diabetic patients. Concerning REDOX markers, we could observe a significant reduction in the TAC in T1DM (mean +− SD ) of 1.32 +− 0.17 against 1.47 +− 0.16 mmol Trolox equiv/ L(p<0.001) but not other oxidative stress markers. In the sequence, we proceed with the analysis of four subgroups: group 1: T1DM without any diabetic complication or high blood pressure and BMI <25kg/m2; group 2: T1DM with any diabetic complication, high blood pressure or BMI >= 25 kg/m2; group 3: normal controls without the high blood pressure and BMI <25kg/m2; group 4: controls with metabolic disease(excluding T2DM)and high blood pressure or BMI >= 25 kg/m2. Analyzing the profile of groups 1,(T1DM without complications) against group 3(normal controls), we noted a reduced TAC (mean +− SD) of 1.34 +− 0.2 in G1 versus 1.47 +− 0.16 mmol Trolox equiv/ L in G3 ( p=0.006). No significant differences were perceived in relation to TOS ( mean +− SD) of 102.33 +− 43 in G1 vs. 88.57 +− 48.7 micromol H2O2 equiv/L in G3, FRAP 287 +− 64.5 in G1 vs 306.6 +− 72 micromol/L in G3, or AOPP 252.11 +− 127 in G1 vs 260.38 +− 152 micromol/L in G3. Our results suggest that a reduction in the total antioxidant capacity is present in normal blood pressure T1DM even without chronic complications. Presentation: Thursday, June 15, 2023