Abstract
Background Familial Mediterranean Fever (FMF) is a chronic hereditary disease which is characterized by recurrent attacks of fever accompanied by serositis. Severity of disease is related with morbidities such as amyloidosis and chronic renal failure. Objectives The aim of this study was to evaluate disease severity with two disease severity scores in FMF patients, and compare them. Methods The study included 160 patients with FMF. Demographic and clinical data were recorded in the patients’ form. The patients’ disease severity were evaluated with International Severity Scoring System for FMF (ISSF) and The Second Set of FMF severity score (F-SS-2). Results A total of 160 patients, comprising of 106 males (66.3%) and 54 (33.8%) females with a mean age of 33.5 ± 12.2 years were evaluated. Mean disease duration was 16.6 ± 10.3 years. Other demographic and clinical characteristics of the patients were shown in Table 1. According to ISSF, 67 (41.9%) patients were classified as having mild disease, 80 (50.0%) patients as intermediate disease and 13 (8.1%) patients as severe disease. On the other hand, 59 (36.9%) patients were classified as having mild disease, 41 (25.6%) patients as intermediate disease and 60 (37.5%) patients as severe disease according to F-SS-2 score. Higher rates of patients were found having severe disease according to F-SS-2 compared with ISSF (p F-SS-2: The second set of Familial Mediterranean Fever severity score, ISSF: International Severity Scoring System for Familial Mediterranean Fever, aPearson Chi-Square test Conclusion Disease severity scores should be used for treatment choice, evaluation of disease prognosis and classify patients according to disease severity in clinical trials. In the current study, we found a difference between the classifications of disease severity, which could be a result of each scoring system uses different parameters of the disease. Disclosure of Interests None declared
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